胡成国

博士 , 副教授
研究方向: 生物电分析、光电化学传感器
联系电话:
Email: cghu@whu.edu.cn


教育与研究经历

1997.9 - 2001.6       武汉大学,化学与分子科学学院,学士

2001.9 - 2006.6       武汉大学,化学与分子科学学院,博士

2006.7 - 2009.11     武汉大学,化学与分子科学学院,讲师

2010.11 - 2011.11   美国奥本大学,访问学者

2009.12 - 至今         武汉大学,化学与分子科学学院,副教授、硕士生导师

 

研究兴趣与领域光电器件与生物传感

电化学传感器是涉及化学、材料、电子、传感、生物、医学和环境等领域的多学科交叉研究方向。血糖仪和各种气体传感器的普及证明了电化学传感技术在便携式/原位分析领域中的应用优势,其在线监测功能也是目前智能穿戴设备的研究热点。然而,与光学分析方法相比,电化学传感技术在大分子标志物检测等高端医学分析领域中的应用很少,主要原因是现有电化学传感体系在灵敏度、重现性和检测通量等方面与光学方法相比还存在差距,涉及传感材料、电极阵列与检测通量等方面。我们的研究兴趣及领域包括:

1碳纳米材料合成方法

A、高分散、高产率氧化石墨烯合成(ACS Appl. Mater. Interfaces 2015, 7, 21356

B、高分散、高导电石墨烯纳米片制备(Carbon 2017, 120, 411

C、高灵敏、高分散富勒烯光电探针合成,其分散、稳定、生物相容和可标记等性能媲美纳米金(Anal Chem 2013, 85, 10612

2电极阵列构筑技术

A、喷墨打印多孔金电极及其气体传感(Anal Chem 2012, 84, 3745

B、模板沉积多孔金电极及其爆炸物原位固体检测(Anal Chem 2014, 86, 8383

C、模板过滤纳米碳基及金属基电极,在材质、成本和性能等方面优于现有丝网印刷技术(ACS Sens 2018, 3, 2518

D、激光雕刻石墨烯电极,可直接在绝缘性高分子材料表面构筑超低成本石墨烯电化学传感器(Carbon 2018, 127, 287

3寻址多目标/高通量检测原理、器件及装置

A、多目标DNA分析(Anal Chem 2015, 87, 9368

B、无标记多目标肿瘤标志物检测(Biosens Bioelectron 2017, 91, 53

C、便携式高通量凝血酶抑制剂筛选(Anal Chem 2018, 90, 9366

D、集成化纸片状高通量光电化学生物传感器,其检测通量可拓展至媲美光学96孔板(专利202110357418.8

4其它研究

A、氧化石墨烯净水剂(J Taiwan Inst Chem E 2018, 88, 137,与华中科技大学合作)

B、低电压、低功耗、宽温度范围石墨烯电热膜的激光雕刻制备(15V/3cm>350℃)

我们的研究工作涉及电化学传感器的材料、技术、原理及装置等方面,潜在就业领域广泛,包括传感、储能、电子、材料、环保、质检等方向的企业或科研院所,相关研究成果具有较好的产业化应用前景,热忱欢迎有志从事相关研究的各位同学加入我们小组。

 

教学情况

仪器分析(化院本科生);现代分析化学(化院本科生);高等分析化学(分析化学专业研究生);仪器分析实验(化院本科生)。

 

承担项目与课题

国家自然科学基金面上项目:基于液滴寻址编码电化学传感阵列的肿瘤细胞活性多指标动态监测方法(2020-2023),主持、在研

国家自然科学基金面上项目:无标记高通量光电生物传感阵列的构建及其凝血酶抑制剂筛选应用(2017-2020),主持、已结题

湖北省自然科学基金面上项目:石墨烯基电化学传感阵列的制备与应用基础研究,主持、已结题

横向课题:壳聚糖基光电化学生物传感器电极芯片(企业合作项目),主持、在研

武汉大学自主科研项目:多目标肿瘤标志物的寻址高通量光电化学分析方法研究,主持、已结题

传感技术国家重点实验室开放基金:基于石墨烯的氮氧自由基微纳米传感器研究,主持、已结题

国家自然科学基金青年基金:新型三维纳米滤膜电化学免疫传感器及其支原体检测应用,主持、已结题

 

代表性成果

1. Mengmeng Song, Lantu Dang, Juan Long, Chengguo Hu*, Laser-Cut Polymer Tape Templates for Scalable Filtration Fabrication of User-Designed and Carbon-Nanomaterial-Based Electrochemical Sensors, ACS Sensors 2018, 3(12), 2518-2525.

2. Juan Wang, Mengmeng Song, Chengguo Hu*, Kangbing Wu*, Portable, Self-Powered, and Light-Addressable Photoelectrochemical Sensing Platforms Using pH Meter Readouts for High-Throughput Screening of Thrombin Inhibitor Drugs, Analytical Chemistry 2018, 90(15), 9366-9373.

3. Zhuchan Zhang, Mengmeng Song, Junxing Hao, Kangbing Wu*, Chunya Li, Chengguo Hu*, Visible Light Laser-Induced Graphene from Phenolic Resin: A New Approach for Directly Writing Graphene-Based Electrochemical Devices on Various Substrates, Carbon 2018, 127, 287-296.

4. Zhuchan Zhang#, Jiaojiao Sun#, Can Lai, Quan Wang, Chengguo Hu*, High-Yield Ball-Milling Synthesis of Extremely Concentrated and Highly Conductive Graphene Nanoplatelet Inks for Rapid Surface Coating of Diverse Substrates, Carbon 2017, 120, 411-418.

5. Juan Wang, Juan Long, Zhihong Liu*, Wangze Wu, Chengguo Hu*, Label-free and High-throughput Biosensing of Multiple Tumor Markers on a Single Light-addressable Photoelectrochemical Sensor, Biosensors and Bioelectronics 2017, 91, 53-59.

6. Juan Wang, Zhihong Liu, Chengguo Hu*, Shengshui Hu, Ultrasensitive Photoelectrochemical Biosensing of Multiple Biomarkers on a Single Electrode by a Light Addressing Strategy, Analytical Chemistry 2015, 87(18), 9368-9375.

7. Jiaojiao Sun, Ningxin Yang, Zhe Sun, Mengqi Zeng, Lei Fu, Chengguo Hu*, Shengshui Hu, Fully Converting Graphite into Graphene Oxide Hydrogels by Preoxidation with Impure Manganese Dioxide, ACS Applied Materials and Interfaces 2015, 7(38), 21356-21363.

8. Guo Jingxing#, Zhang Tao#, Hu Chengguo*, Fu Lei*, A Three-dimensional Nitrogen-doped Graphene Structure: a Highly Efficient Carrier of Enzymes for Biosensors, Nanoscale 2015, 7(4), 1290-1295.

9. Juan Wang , Wei Jin , Xing Zhang , Chengguo Hu*, Qing-Ying Luo , Yi Lin , and Shengshui Hu*, Rapid in Situ Detection of Ultratrace 2,4-Dinitrotoluene Solids by a Sandwiched Paper-like Electrochemical Sensor, Analytical Chemistry 2014, 86(16), 8383-8390 (Reported in ChemistryViews as “Detecting Ultratrace Solid Dinitrotoluene” ).

10. Chengguo Hu*, Jinou Zheng, Xiaoyang Su, Juan Wang, Wangze Wu, and Shengshui Hu*, Ultrasensitive All-Carbon Photoelectrochemical Bioprobes for Zeptomole Immunosensing of Tumor Markers by an Inexpensive Visible Laser Light, Analytical Chemistry 2013, 85(21), 10612-10619 (Reported in CEN as “An Ultrasensitive, Carbon-Based Probe For Biomolecules”).

11. Chengguo Hu*, Xiaoyun Bai, Yingkai Wang, Wei Jin, Xuan Zhang, Shengshui Hu*, Inkjet Printing of Nanoporous Gold Electrode Arrays on Cellulose Membranes for High-Sensitive Paper-Like Electrochemical Oxygen Sensors Using Ionic Liquid Electrolytes, Analytical Chemistry 2012, 84(8), 3745–3750.

12. Chengguo Hu, Yan Ding, Yiping Ji, Junhui Xu, Shengshui Hu*, Fabrication of thin-film electrochemical sensors from single-walled carbon nanotubes by vacuum filtration, Carbon 2010, 48(5), 1345-1352.

13. Junhui Xu, Chengguo Hu*, Yiping Ji, Shengshui Hu*, Ultrathin Gold Film Deposited on Human Hair: Derivation from Nanoparticles and Applications as Microsensors, Electrochemistry Communications 2009, 11(4), 764-767.

14. Chengguo Hu*, Shengshui Hu, Surface Design of Carbon Nanotubes for Optimizing the Adsorption and Electrochemical Response of Analytes, Langmuir 2008, 24(16), 8890-8897.

15. Dongyun Zheng, Chengguo Hu*, Yanfen Peng, Wanqing Yue, Shengshui Hu*, Noncovalently Functionalized Water-soluble Multiwall-nanotubes through Azocarmine B and Their Application in Nitric Oxide Sensor, Electrochemistry Communications 2008, 10(1), 90-94.

16. Chengguo Hu, Chunhai Yang, Shengshui Hu*, Hydrophobic Adsorption of Surfactants on Water-soluble Carbon Nanotubes: a Simple Approach to Improve Sensitivity and Antifouling Capacity of Carbon Nanotubes-based Electrochemical Sensors, Electrochemistry Communications 2007, 9(1), 128-134.

17. Chengguo Hu, Zilin Chen, Aiguo Shen, Xincheng Shen, Jie Li, Shengshui Hu*, Water-soluble Single-walled Carbon Nanotubes via Noncovalent Functionalization by a Rigid, Planar and Conjugated Diazo Dye, Carbon 2006, 44(3), 428-434.

 

发明专利

1. 胡成国,石墨烯-陶瓷复合电极阵列的激光雕刻制备方法及其应用,专利申请号:201910973700.1

2. 胡成国,一种低背景石墨烯电极阵列的激光雕刻制备方法及电化学传感器制备方法,专利申请号:201910774866.0

3. 胡成国,杨佳,一种水分散性碳纳米材料的高效纯化方法,专利申请号:201910674749.7

4. 胡成国,宋梦梦,一种碳基及金属基电极阵列的低成本高精度制备方法,专利申请号:201710970329.4

5. 胡成国,张祝潺,一种高导电石墨烯薄膜阵列的激光雕刻制备方法,专利申请号:201710758366.9

6. 胡成国,孙姣姣,杨宁馨,孙哲,胡胜水,一种高分散性氧化石墨烯水凝胶的合成方法,授权专利号:201510067975.0

7. 胡成国,胡胜水,杨宁馨,孙哲,一种高导电石墨烯和石墨烯导电膜及其制备方法,授权专利号:201310434073.7 (已转让国内矿山企业)

8. 胡成国,胡胜水,邱鸿,李群,吴澄屹,一种石墨导电薄膜及其制备方法与应用,授权专利号:201310489211.1

9. 胡成国,胡胜水,郑金偶,一种高灵敏富勒烯光电化学探针及其制备方法,授权专利号:201310367405.4

10. 胡胜水,胡成国,一种水溶性碳纳米管的制备方法,授权专利号: 200410060849.4

 

获奖与荣誉

2010年获湖北省自然科学二等奖(排名3