宋恒

博士 , 教授
研究方向：化学生物学、合成生物学、酶催化
联系电话：
Email: hengsong@whu.edu.cn

宋恒，武汉大学化学与分子科学学院教授、博士生导师。研究领域为合成生物学、化学生物学和生物医学工程的交叉领域。

教育与研究经历：

2018至今教授、博导，武汉大学化学与分子科学学院

2015 – 2018 博士后，劳伦斯伯克利国家实验室和加州大学伯克利分校

2010 – 2015 博士，波士顿大学化学系

2005 – 2009 学士，南京大学化学系

研究领域与兴趣：化学生物学、合成生物学、生物工程、酶催化、小分子探针在生物过程中的检测应用、蛋白工程改造、代谢工程生产、生物信息学和化学信息学。

欢迎有志于合成生物学和化学生物学以及生物工程方向的、致力于复合型学科研究的青年才俊前来交流、切磋和学习；欢迎参加武汉大学“优秀大学生暑期夏令营”的同学咨询宋老师实验室相关情况；欢迎优秀学子报考宋老师化学和生物学交叉方向实验室的推免研究生、博士生和研究生。

此外，因研究工作需要，实验室长期招募优秀的博士后研究员（年薪20-30万）和研究助理（年薪6万以上），享受武汉大学相关福利政策，待遇非常优厚，欢迎来信垂询。

发表论文：

1. Li Chen, Nathchar Naowarojna, Heng Song, Shu Wang, Jiangyun Wang, Zixin Deng, Changming Zhao, Pinghua Liu, Use of a Tyrosine Analogue To Modulate the Two Activities of a Nonheme Iron Enzyme OvoA in Ovothiol Biosynthesis, Cysteine Oxidation versus Oxidative C–S Bond Formation, Journal of the American Chemical Society, 2018, 140, 4604.

2. Wupeng Yan^#, Heng Song^#, Fuhang Song, Cheng-Hsuan Wu, Ampon Sae Her, Yi Pu, Shu Wang, Catherine E. Costello, Lixin Zhang, Pinghua Liu, and Yan Zhang. “Endoperoxide Formation Catalyzed by FtmOx1, an α-Ketoglutarate-dependent Mononuclear Non-heme Iron Enzyme”, Nature. 2015, 527, 539.(#共同第一作者)

3. Heng Song, Wen Hu, Nathchar Naowarojna, Ampon Sae Her,Shu Wang, Rushil Desai, Li Qin,* Xiaoping Chen,* and Pinghua Liu*. “Mechanistic studies of a novel C-S lyase in ergothioneine biosyntheses: the involvement of a sulfenic acid intermediate”, Scientific Reports. 5, 11870. (2015).

4. Wen Hu,^# Heng Song,^# Ampon Sae Her, Dan Bak, Zhibin Zhen, Sean Elliott, Li Qin,* Xiaoping Chen,* Pinghua Liu*. “Bioinformatic and Biochemical Characterizations of C–S Bond Formation and Cleavage Enzymes in the Fungus Neurospora crassa Ergothioneine Biosynthetic Pathway”, Organic Letter. 16, 5382–5385. (2014) (#共同第一作者)

5. Heng Song, Ampon Sae Her, Fiona Raso, Zhibin Zhen, and Pinghua Liu*,” Cysteine Oxidation Reactions Catalyzed by a Mononuclear Non-heme Iron Enzyme (OvoA) in Ovothiol Biosynthesis”, Organic Letter, 16, 2122−2125. (2014)

6. Heng Song, Maureen Leninger, Norman Lee, and Pinghua Liu*,” Biosynthetic Studies of Two Sulfur-containing Natural Products: Ergothioneine and Ovothiol”, Organic Letter, 15, 4854 - 4857. (2013)

7. Wei-chen Chang, Heng Song, Hung-wen Liu*, and Pinghua Liu*. “Current Development in Isoprenoid Precursor Biosynthesis and Regulation”, Current Opinion in Chemical Biology, 17, 571-579. (2013)

8. Bin Sun, Yang Zhang, Ke-Jun Gu, Qun-Dong Shen,* Yan Yang, and Heng Song. Layer-by-Layer Assembly of Conjugated Polyelectrolytes on Magnetic Nanoparticle Surfaces. Langmuir, 25, 10, 5969-5973 (2009)

9.Heng Song, Bin Sun, Ke-Jun Gu,Yan Yang, Yang Zhang, Qun-Dong Shen*. Interactions between Cationic Conjugated Polyelectrolytes and DNA and a Label-Free Method for DNA Detection Based on Conjugated Polyelectrolyte Complexes, Journal of Applied Polymer Science, 114, 1278–1286 (2009)

授权专利：

Pinghua Liu, Heng Song and Wen Hu. Production of ergothioneine by metabolic engineering. 2014 美国授权专利 (WO 2014100752 A1).