Yuan Bi Feng

Yuan Bi Feng

Doctor , Professor
Research: Mass spectrometry / Nucleic acid chemical biology
Phone: 化西109B
Email: bfyuan@whu.edu.cn

Education and Research Experience

1997. 9 - 2001. 6       Wuhan University   B.S.

2001. 9 - 2006. 6       Wuhan University   Ph.D

2006. 11 - 2007. 6     National University of Singapore      Postdoc

2007. 7 - 2010. 12     University of California, Riverside     Postdoc

2011. 1 -                    Wuhan University                              Professor

 

Research Interests

  1. Epigenetic Modifications

  2. Metabolomics

  3. Nucleic acid damage and repair 


Selected Publications

  1. You, X.J., Liu, T., Ma, C.J., Qi, C.B., Tong, Y., Zhao, X., Yuan, B.F.* and Feng, Y.Q. (2019) Determination of RNA hydroxylmethylation in mammals by mass spectrometry analysis. Anal Chem, 91, 10477-10483.

  2. Tang, F., Liu, S., Li, Q.Y., Yuan, J., Li, L., Wang, Y., Yuan, B.F.* and Feng, Y.Q. (2019) Location analysis of 8-oxo-7,8-dihydroguanine in DNA by polymerase-mediated differential coding. Chem Sci, 10, 4272–4281.

  3. Xiong, J., Ye, T.T., Ma, C.J., Cheng, Q.Y., Yuan, B.F.* and Feng, Y.Q. (2019) N6-Hydroxymethyladenine: a hydroxylation derivative of N6-methyladenine in genomic DNA of mammals. Nucleic Acids Res, 47, 1268-1277.

  4. Chen, B., Yuan, B.F.* and Feng, Y.Q. (2019) Analytical Methods for Deciphering RNA Modifications. Anal Chem, 91, 743-756.

  5. Xu, J., Zhang, Q.F., Zheng, J., Yuan, B.F.* and Feng, Y.Q.* (2019) Mass spectrometry-based fecal metabolome analysis. TrAC-Trend Anal Chem, 112, 161-174.

  6. Ma, C.J., Ding, J.H., Ye, T.T., Yuan, B.F.* and Feng, Y.Q. (2019) AlkB Homologue 1 Demethylates N(3)-Methylcytidine in mRNA of Mammals. ACS Chem Biol, 14, 1418-1425.

  7. Li, Q.Y., Xie, N.B., Xiong, J., Yuan, B.F.* and Feng, Y.Q. (2018) Single-Nucleotide Resolution Analysis of 5-Hydroxymethylcytosine in DNA by Enzyme-Mediated Deamination in Combination with Sequencing. Anal Chem, 90, 14622-14628.

  8. Chu, J.M., Ye, T.T., Ma, C.J., Lan, M.D., Liu, T., Yuan, B.F.* and Feng, Y.Q. (2018) Existence of Internal N7-Methylguanosine Modification in mRNA Determined by Differential Enzyme Treatment Coupled with Mass Spectrometry Analysis. ACS Chem Biol. 13, 3243−3250

  9. Jiang, H.P., Xiong, J., Liu, F.L., Ma, C.J., Tang, X.L., Yuan, B.F.* and Feng, Y.Q. (2018) Modified nucleoside triphosphates exist in mammals. Chem Sci, 9, 4160-4167.

  10. Yuan, B.F., Zhu, Q.F., Guo, N., Zheng, S.J., Wang, Y.L., Wang, J., Xu, J., Liu, S.J., He, K., Hu, T., Zheng, Y.W., Xu, F.Q. and Feng, Y.Q.* (2018) Comprehensive Profiling of Fecal Metabolome of Mice by Integrated Chemical Isotope Labeling-Mass Spectrometry Analysis. Anal Chem, 90, 3512-3520.

  11. Lan, M.D., Xiong, J., You, X.J., Weng, X.C., Zhou, X., Yuan, B.F.* and Feng, Y.Q. (2018) Existence of Diverse Modifications in Small-RNA Species Composed of 16-28 Nucleotides. Chem-Eur J, 24, 9949-9956.

  12. Zeng, H., Qi, C.B., Liu, T., Xiao, H.M., Cheng, Q.Y., Jiang, H.P., Yuan, B.F.* and Feng, Y.Q. (2017) Formation and Determination of Endogenous Methylated Nucleotides in Mammals by Chemical Labeling Coupled with Mass Spectrometry Analysis. Anal Chem, 89, 4153-4160.

  13. Xiong, J., Liu, X., Cheng, Q.Y., Xiao, S., Xia, L.X., Yuan, B.F.* and Feng, Y.Q. (2017) Heavy Metals Induce Decline of Derivatives of 5-Methycytosine in Both DNA and RNA of Stem Cells. ACS Chem Biol, 12, 1636-1643.

  14. Tang, F., Yu, Q.W., Yuan, B.F.* and Feng, Y.Q.* (2017) Hydrophilic materials in sample pretreatment. TrAC-Trend Anal Chem, 86, 172-184.

  15. Huang, W., Lan, M.D., Qi, C.B., Zheng, S.J., Wei, S.Z., Yuan, B.F.* and Feng, Y.Q. (2016). Formation and determination of the oxidation products of 5-methylcytosine in RNA. Chem Sci. 2016, 7, 5495-5502.

  16. Zhang, H.Y., Xiong, J., Qi, B.L., Feng, Y.Q.* and Yuan, B.F.* (2016) The existence of 5-hydroxymethylcytosine and 5-formylcytosine in both DNA and RNA in mammals. Chem Commun (Camb), 52, 737-740

  17. Huang, W., Qi, C.B., Lv, S.W., Xie, M., Feng, Y.Q.*, Huang, W.H.* and Yuan, B.F.* (2016) Determination of DNA and RNA Methylation in Circulating Tumor Cells by Mass Spectrometry. Anal Chem. 88, 1378-1384.

  18. Xu, J., Wu, P., Ye, E.C., Yuan, B.F.* and Feng, Y.Q.* (2016) Metal oxides in sample pretreatment. TrAC-Trend Anal Chem, 80, 41-56.

  19. Li, X.S., Yuan, B.F.* and Feng, Y.Q.* (2016) Recent advances in phosphopeptide enrichment: Strategies and techniques. TrAC-Trend Anal Chem, 78, 70-83.

  20. Tang, Y., Zheng, S.J., Qi, C.B., Feng, Y.Q.* and Yuan, B.F.* (2015) Sensitive and simultaneous determination of 5-methylcytosine and its oxidation products in genomic DNA by chemical derivatization coupled with liquid chromatography-tandem mass spectrometry analysis. Anal Chem, 87, 3445-3452.

  21. Chu, J.M., Qi, C.B., Huang, Y.Q., Jiang, H.P., Hao, Y.H., Yuan, B.F.* and Feng, Y.Q.* (2015) Metal Oxide-Based Selective Enrichment Combined with Stable Isotope Labeling-Mass Spectrometry Analysis for Profiling of Ribose Conjugates. Anal Chem, 87, 7364-7372.

  22. Shen, F., Huang, W., Huang, J.T., Xiong, J., Yang, Y., Wu, K., Jia, G.F., Chen, J., Feng, Y.Q.*, Yuan, B.F.*, Liu, S.M.* (2015) Decreased N(6)-Methyladenosine in Peripheral Blood RNA From Diabetic Patients Is Associated With FTO Expression Rather Than ALKBH5. J Clin Endocrinol Metab, 100, E148-154.

  23. Yuan, B.F.* and Feng, Y.Q. (2014) Recent advances in the analysis of 5-methylcytosine and its oxidation products. TrAC-Trend Anal Chem, 54, 24-35.

  24. Xing, X.W., Tang, F., Wu, J., Chu, J.M., Feng, Y.Q., Zhou, X.* and Yuan, B.F.* (2014) Sensitive detection of DNA methyltransferase activity based on exonuclease-mediated target recycling. Anal Chem, 86, 11269-11274.

  25. Tang, Y., Xiong, J., Jiang, H.P., Zheng, S.J., Feng, Y.Q.* and Yuan, B.F.* (2014) Determination of oxidation products of 5-methylcytosine in plants by chemical derivatization coupled with liquid chromatography/tandem mass spectrometry analysis. Anal Chem, 86, 7764-7772.

  26. Qi, B.L., Liu, P., Wang, Q.Y., Cai, W.J., Yuan, B.F.* and Feng, Y.Q.* (2014) Derivatization for liquid chromatography-mass spectrometry. TrAC-Trend Anal Chem, 59, 121-132.

  27. Liu, P., Huang, Y.Q., Cai, W.J., Yuan, B.F.* and Feng, Y.Q.* (2014) Profiling of thiol-containing compounds by stable isotope labeling double precursor ion scan mass spectrometry. Anal Chem, 86, 9765-9773.

  28. Wang, S.T., Huang, W., Lu, W., Yuan, B.F.* and Feng, Y.Q.* (2013) TiO2-Based Solid Phase Extraction Strategy for Highly Effective Elimination of Normal Ribonucleosides before Detection of 2'-Deoxynucleosides/Low-Abundance 2'-O-Modified Ribonucleosides. Anal Chem, 85, 10512-10518.

  29. Tang, Y., Chu, J.M., Huang, W., Xiong, J., Xing, X.W., Zhou, X., Feng, Y.Q.* and Yuan, B.F.* (2013) Hydrophilic material for the selective enrichment of 5-hydroxymethylcytosine and its liquid chromatography-tandem mass spectrometry detection. Anal Chem, 85, 6129-6135.

  30. Chen, M.L., Shen, F., Huang, W., Qi, J.H., Wang, Y., Feng, Y.Q.*, Liu, S.M.* and Yuan, B.F.* (2013) Quantification of 5-Methylcytosine and 5-Hydroxymethylcytosine in Genomic DNA from Hepatocellular Carcinoma Tissues by Capillary Hydrophilic-Interaction Liquid Chromatography/Quadrupole TOF Mass Spectrometry. Clin Chem, 59, 824-832.

  31. Chen, M.L., Liu, Y.L., Xing, X.W., Zhou, X., Feng, Y.Q.* and Yuan, B.F.* (2013) Preparation of a Hyper-cross-linked Polymer Monolithic Column and Its Application to the Sensitive Determination of Genomic DNA Methylation. Chem-Eur J, 19, 1035-1041.

  32. Tang, Y., Gao, X.D., Wang, Y., Yuan, B.F.* and Feng, Y.Q.* (2012) Widespread existence of Cytosine methylation in yeast DNA measured by gas chromatography/mass spectrometry. Anal Chem, 84, 7249-7255.

  33. Yuan, B.F., Zhang, J., Wang, H., Xiong, L., Cai, Q., Wang, T., Jacobsen, S., Pradhan, S. and Wang, Y.* (2011) 6-Thioguanine reactivates epigenetically silenced genes in acute lymphoblastic leukemia cells by facilitating proteasome-mediated degradation of DNMT1. Cancer Res, 71, 1904-1911.

  34. Yuan, B.F., Wang, J., Cao, H., Sun, R. and Wang, Y.* (2011) High-throughput analysis of the mutagenic and cytotoxic properties of DNA lesions by next-generation sequencing. Nucleic Acids Res, 39, 5945-5954.

  35. Yuan, B.F., O'Connor, T.R. and Wang, Y.* (2010) 6-Thioguanine and S(6)-Methylthioguanine Are Mutagenic in Human Cells. ACS Chem. Biol., 5, 1021-1027.

  36. Yuan, B.F., Cao, H., Jiang, Y., Hong, H. and Wang, Y.* (2008) Efficient and accurate bypass of N2-(1-carboxyethyl)-2'-deoxyguanosine by DinB DNA polymerase in vitro and in vivo. Proc. Natl. Acad. Sci. U S A., 105, 8679-8684.

  37. Yuan, B.F., Zhuang, X.Y., Hao, Y.H. and Tan, Z.* (2008) Kinetics of base stacking-aided DNA hybridization. Chem Commun (Camb), 6600-6602.


Full publications link

https://scholar.google.com/citations?user=jrzBHhAAAAAJundefinedamp;hl=en


http://orcid.org/0000-0001-5223-4659