许小娟

博士 , 教授
研究方向: 多糖的结构与功能
联系电话:
Email: xuxj@whu.edu.cn

教育与研究经历  

1993.9-1997.6,理学学士,武汉大学化学学院

1997.9-2002.6,理学博士,武汉大学化学与分子科学学院(导师:张俐娜教授)

2000.4-2001.3,特别研究生,日本大阪大学理学部高分子科学系(从事多糖溶液性质研究,导师:则末尚志教授)

2001.7-现在,助教、讲师、副教授、教授/博导,武汉大学化学与分子科学学院

2008.11-2010.10,日本学术振兴会(JSPS)外国人特别研究员,日本神户大学(从事多糖结构-活性相关性研究)

                                                                                                                                                                                                                                                                    

研究兴趣

1、碳水化合物的多尺度结构、溶液性质及品质功能

2、多糖基复合物及功能

3、多糖的生物活性、构效关系及作用机制


                                                                                                                                                                                                                                                                    


学术兼职     


中国化学会高分子专业委员会高分子表征学科组委员

Bioactive Carbohydrates and Dietary Fibres 期刊编委

International Journal of Biochemistry and Molecular Biology Research  期刊编委

                                                                                                                                                                                                                                                                    


教学情况


本科生课程:《高分子导论》、《高分子合成与表征》、《高分子物理》

研究生课程:《高分子物理当代研究方法》、《高分子科学进展》

                                                                                                                                                                                                                                                                    


承担项目


1国家自然科学基金21875167,2019.1-2022.12。(主持)

2、国家自然科学基金215741022016.1-2019.12。(主持)

3、教育部新世纪优秀人才支持计划NCET-13-04422014.1-2016.12。(主持)

4、武汉大学中央高校基本科研业务基金项目(2042014kf0216),2014.1-2015.12。(主持)

5、国家自然科学重点基金213340052014.1-2017.12。(参加)

6、武汉市“黄鹤英才计划”,2013.1-2016.12。(主持)

7、国家自然科学基金212741142013.1-2016.12。(主持)

8、国家自然科学基金208740782009.1-2011.12。(主持)

9、武汉市青年科技晨光计划200950431193 2009.1-2011.12。(主持)

10、国家自然科学基金204040102005.1-2007.12。(主持)

11、湖北省自然科学基金, 2005.1-2006.12。(主持)

                                                                                                                                                                                                                                                                    

代表性论文

1. Zhaohua Ping, Ting Liu, Hui Xu, Yan Meng, Wenhua Li, Xiaojuan Xu*, Lina Zhang*. Construction of highly stable selenium nanoparticles embedded in hollow nanofibers of polysaccharide and their antitumor activities. Nano Res. 2017, 10, 3775–3789.

2. Xing Zheng, Fuling Zhou, Xiaojuan Xu*, Lina Zhang*. Uptake of intraperitoneally administered triple helical β-glucan for antitumor in murine tumor models. J. Mater. Chem. B 2017, 5, 9337-9345.

3. Qingye Liu, Bingchao Duan, Xiaojuan Xu*, Lina Zhang. Progress in rigid polysaccharides-based nanocomposites with therapeutic functions. J. Mater. Chem. B 2017, 5, 5690 – 5713.

4. Xueqin Wei, Jiangjiang Duan, Xiaojuan Xu*, Lina Zhang*. Highly efficient one-step purification of sulfated polysaccharides via chitosan microspheres adsorbents. ACS Sustainable Chem. Eng. 2017, 5(4), 3195-3203.

5. Hui Xu#, Siwei Zou#, Xiaojuan Xu*, Lina Zhang. β-Glucan from Lentinus edodes suppresses cell proliferation and promotes apoptosis in estrogen receptor positive breast cancers. Oncotarget 2017, 8(49), 86693-86709.

6. Yan Cao, Siwei Zou, Hui Xu, Mengxia Li, Zan Tong, Min Xu, Xiaojuan Xu*. Hypoglycemic activity of the Baker’s yeast β-glucan in obese/type 2 diabetic mice and the underlying mechanism. Mol. Nutr. Food Res. 2016, 60 (12), 2678-2690.

7. Hui Xu, Siwei Zou, Xiaojuan Xu*, Lina Zhang. Anti-tumor effect of β-glucan from Lentinus edodes and the underlying mechanism. Sci. Rep. 2016, 6: 28802.

8. Liu Q., Cao Y., Xu H., Li M., Xu X.*, Zhang L. Transfection efficiency and internalization of the gene carrier prepared from a triple helical b-glucan and polydeoxyadenylic acid in macrophage RAW264.7 cells, J. Mater. Chem. B, 2015, 3, 3789-3798.

9. Fang Y., Duan B., Lu A., Liu M., Liu H., Xu X.*, Zhang L.* Intermolecular interaction and the extended wormlike chain conformation of chitin in NaOU/urea aqueous solution, Biomacromolecules, 2015,16,1410-1417.

10. Liu Q., Wang C.,  Cao Y.,  Xu X.*,  Zhang L. A novel gene delivery system prepared from beta-glucan and polydeoxyadenylic acid via disulfide bonds. J. Mater. Chem. B, 2014, 2, 933-944. 

11. Jia X., Xu X.*, Zhang L. Synthesis and Stabilization of Gold Nanoparticles Induced by Denaturation and Renaturation of Triple Helical b-Glucan in Water. Biomacromolecules, 2013,14, 1787-1794.

12. Xu S., Lin Y., Huang J., Li Z., Xu X.*, Zhang L.* Construction of high strength hollow fibers by self-assembly of a stiff polysaccharide with short branches in water. J. Mater., Chem. A, 2013, 1, 4198-4206.

13. Xu X.*, Yasuda M., Nakamura-Tsuruta S., Mizuno M., Ashida H.* β-glucan from Lentinus edodes inhibits nitric oxide and tumor necrosis factor-a and phosphorylation of mitogen-activated protein kinases in lipopolysaccharide stimulated murine RAW 264.7 macrophages. J. Biol. Chem., 2012, 287, 871-878.

14. Xu X.*, Chen P., Zhang L., Ashida H. Immunomodulatory b-glucan from Lentinus edodes activates mitogen-activated protein kinases and nuclear factor-kB in murine RAW 264.7 macrophages. J. Biol. Chem., 2011, 286, 31194-31198.

15. Xu X., Zhang X., Zhang L., Wu C. Collapse and association of denatured lentinan in water / dimethylsulfoxide solution, Biomacromolecules, 2004, 5, 1893-189.