刘晓庆

博士 , 教授
研究方向: 分析化学
联系电话: 136-1866-0366 (化中213,工学部九教A9422)
Email: xiaoqingliu(at)whu.edu.cn


课题组主页: http://xiaoqingliu.whu.edu.cn

教育与研究经历:

    2003年在山东师范大学化学化工与材料科学学院取得学士学位,2009年初从中国科学院长春应用化学研究所、电分析化学国家重点实验室获得博士学位,获中科院刘永龄奖学金特别奖。2009至2015年先后在丹麦奥胡斯大学化学系、交叉学科纳米中心以及以色列耶路撒冷希伯来大学化学研究所、纳米科学与技术中心做博士后研究工作。2015年加入武汉大学化学与分子科学学院、生物医学分析化学教育部重点实验室,任教授、博士生导师,入选国家青年千人计划(2015)。

研究领域与兴趣:

     生物传感及医学分析,核酸纳米技术,纳米医学材料。包括功能材料与界面的构筑及其生物传感研究,核酸结构的组装、调控与生物医学应用,先进纳米材料的制备及其在药物递送与肿瘤治疗中的应用。相关成果发表在J. Am. Chem. Soc., Angew. Chem. Int. Ed., ACS Nano, Nano Lett., Adv. Mater., Anal. Chem., Acc. Chem. Res.等国际知名期刊,授权专利5项。

招生招聘:

    在这里,有武大强力的学科支撑,有化院完善的科研条件,有积极向上、友爱互助的课题组氛围。欢迎具有化学、生物、医学或材料背景的本科生、研究生以及博士后加入我们。

论文专利:

 论文:

    1.    Huimin Wang, Yuqi Chen, Hong Wang, Xiaoqing Liu, Xiang Zhou, Fuan Wang*. DNAzyme-Loading MOFs for Self-Sufficient Gene Therapy. Angew. Chem. Int. Ed. 2019, 58, 7380-7384. DOI: 10.1002/anie.201902714

    2.     Jing Wang, Huimin Wang, Hong Wang, Shizhen He, Ruomeng Li, Zhao Deng, Xiaoqing Liu, Fuan Wang*, Nonviolent Self-Catabolic DNAzyme Nanosponges for Smart Anticancer Drug Delivery. ACS Nano.2019, 13, 5852-5863. DOI: 10.1021/acsnano.9b01589

    3.     Qiong Wu, Gang Chen, Keke Gong, Jing Wang, Xiaoxiao Ge, Xiaoqing Liu, Shaojun Guo*, FuanWang*. MnO2-Laden Black Phosphorus for MRI-Guided Synergistic PDT, PTT, and Chemotherapy. Matter 2019, 1, 496-512. DOI: 10.1016/j.matt.2019.03.007

    4.     Junlin Sun, Feng Liu, Wenqian Yu, Qunying Jiang, Jialing Hu, Yahua Liu, Fuan Wang, Xiaoqing Liu*, Highly Sensitive Glutathione Assay and Intracellular Imaging with Functionalized Semiconductor Quantum Dots. Nanoscale, 2019, 11, 5014-5020.

    5.     Jie Feng, Zhen Xu, Ping Dong, Wenqian Yu, Feng Liu, Qunying Jiang, Fuan Wang, Xiaoqing Liu*, Stimuli-Responsive Multifunctional  Metal-Organic Framework Nanoparticles for Enhanced Chemo-Photothermal Therapy. J Mater. Chem. B, 2019, 7, 994-1004.

    6.     Yahua Liu, Min Pan, Wenxiao Wang, Qunying Jiang, Fuan Wang, Dai-Wen Pang, Xiaoqing Liu*, Plasmonic and Photothermal Immunoassay via Enzyme-Triggered Crystal Growth on Gold Nanostars. Anal. Chem., 2019, 91, 2086–2092.

    7.     Yahua Liu, Ping Dong, Qunying Jiang, Fuan Wang, Dai-Wen Pang, Xiaoqing Liu*, Assembly-Enhanced Fluorescence from Metal Nanoclusters and Quantum Dots for Highly Sensitive Biosensing. Sens. Actuators B Chem., 2019, 279, 334–341.

    8.     Xue Gong, Jie Wei, Jing Liu, Ruomeng Li, Xiaoqing Liu, Fuan Wang*. Programmable Intracellular DNA Biocomputing Circuits for Reliable Cell Recognitions. Chem. Sci., 2019, 10, 2989-2997.

    9.     Lei Yang, Qiong Wu, Yuqi Chen, Xiaoqing Liu, Fuan Wang*, Xiang Zhou, Amplified MicroRNA Detection and Intracellular Imaging Based on an Autonomous and Catalytic Assembly of DNAzyme. ACS Sens. 2019, 4, 110-117.

10.     Min Pan, Zhen Xu, Qunying Jiang, Jie Feng, Fuan Wang, Xiaoqing Liu*. Interfacial Engineering of Carbon Dots with Benzenediboronic Acid for Fluorescent Biosensing. Nanoscale Adv. 2019, 1, 765-771.

11.     Jie Feng, Zhen Xu, Feng Liu, Yun Zhao, Wenqian Yu, Min Pan, Fuan Wang, Xiaoqing Liu*, Versatile Catalytic Deoxyribozyme Vehicles for Multimodal Imaging-Guided Efficient Gene Regulation and Photothermal Therapy. ACS Nano, 2018, 12, 12888–12901.

12.     Min Pan, Meijuan Liang, Junlin Sun, Xiaoqing Liu*, Fuan Wang*. Lighting Up Fluorescent Silver Clusters via Target-Catalyzed Hairpin Assembly for Amplified Biosensing. Langmuir 2018, 34, 14851–14857.

13.     Meijuan Liang, Min Pan, Jialing Hu, Fuan Wang, Xiaoqing Liu*. Electrochemical Biosensor for MicroRNA Detection Based on Cascade Hybridization Chain Reaction. ChemEletroChem 2018, 5, 1380–1386.

14.     Chunxiao Li, Huimin Wang, Jinhua Shang, Xiaoqing Liu, Bi-Feng Yuan, Fuan Wang*, Highly Sensitive Assay of Methyltransferase Activity Based on an Autonomous Concatenated DNA Circuit, ACS Sens. 2018, 3, 2359–2366.

15.     Huimin Wang, Chunxiao Li, Xiaoqing Liu, Xiang Zhou, Fuan Wang*. Construction of an Enzyme-Free Concatenated DNA Circuit for Signal Amplification and Intracellular Imaging. Chem. Sci. 2018, 9, 5842–5849.

16.     Jie Wei, Xue Gong, Qing Wang, Min Pan, Xiaoqing Liu, Jing Liu, Fan Xia, Fuan Wang*, Construction of an Autonomously Concatenated Hybridization Chain Reaction for Signal Amplification and Intracellular Imaging. Chem. Sci. 2018, 9, 52–61.

17.     Qiong Wu, Meijuan Liang, Simin Zhang, Xiaoqing Liu, Fuan Wang*. Development of Functional Black Phosphorus Nanosheets with Remarkable Catalytic and Antibacterial Performance. Nanoscale 2018, 10, 10428–10435.

18.     Qing Wang, Min Pan, Jie Wei, Xiaoqing Liu, Fuan Wang*. Evaluation of DNA Methyltransferase Activity and Inhibition via Isothermal Enzyme-Free Concatenated Hybridization Chain Reaction. ACS Sens. 2017, 2, 932–939.

19.     Jing Wang, Min Pan, Jie Wei, Xiaoqing Liu, Fuan Wang*, A C-HCR Assembly of Branched DNA Nanostructures for Amplified Uracil-DNA Glycosylase Assays. Chem. Commun. 2017, 53, 12878–12881.

20.     Fuan Wang†, Xiaoqing Liu†, Itamar Willner*, DNA Switches: From Principles to Applications. Angew. Chem. Int. Ed. 2015, 54, 1098–1129. (†Equal Contribution)

21.     Xiaoqing Liu†, Chun-Hua Lu†, Itamar Willner*, Switchable Reconfiguration of Nucleic Acid Nanostructures by Stimuli-Responsive DNA Machines. Acc. Chem. Res. 2014, 47, 1673–1680. DOI: 10.1021/ar400316h

22.     Lianzhe Hu†, Xiaoqing Liu†, Alessandro Cecconello, Itamar Willner, Dual Switchable CRET-Induced Luminescence of CdSe/ZnS Quantum Dots (QDs) by the Hemin/G-Quadruplex-Bridged Aggregation and Deaggregation of Two-Sized QDs. Nano Lett. 2014, 14, 6030-6035. (†Equal Contribution)

23.     Fuan Wang, Chun-Hua Lu, Xiaoqing Liu, Lina Freage, Itamar Willner*, Amplified and Multiplexed Detection of DNA Using the Dendritic Rolling Circle Amplified Synthesis of DNAzyme Reporter Units. Anal. Chem. 2014, 86, 1614–1621. DOI: 10.1021/ac4033033

24.     Chun-Hua Lu, Xiu-Juan Qi, Xiaoqing Liu, Simcha Shimron, Huang-Hao Yang, Itamar Willner*, Autonomous Control of Interfacial Electron Transfer and the Activation of DNA Machines by an Oscillatory pH System. Nano Lett. 2013, 13, 4920–4924, DOI: 10.1021/nl402873y

25.     Xiaoqing Liu, Fuan Wang, Ruth Aizen, Omer Yehezkeli, Itamar Willner*, Graphene Oxide/Nucleic Acid-Stabilized Silver Nanoclusters: Functional Hybrid Materials for Optical Aptamer Sensing and Multiplexed Analysis of Pathogenic DNAs. J. Am. Chem. Soc. 2013, 135, 11832–11839. DOI: 10.1021/ja403485r

26.     Fuan Wang, Xiaoqing Liu, Chun-Hua Lu, Itamar Willner*, Cysteine-Mediated Aggregation of Au Nanoparticles: The Development of a H2O2 Sensor and Oxidase-Based Biosensors. ACS Nano, 2013, 7, 7278–7286. DOI: 10.1021/nn402810x

27.     Gilad Pelossof, Ran Tel-Vered, Xiaoqing Liu, Itamar Willner*, Switchable Mechanical DNA “Arms” Operating on Nucleic Acid Scaffolds Associated with Electrodes or Semiconductor Quantum Dots. Nanoscale, 2013, 5, 8977–8981. DOI: 10.1039/C3NR02653A

28.     Xiaoqing Liu, Fuan Wang, Angelica Niazov-Elkan, Weiwei Guo, Itamar Willner*, Probing Biocatalytic Transformations with Luminescent DNA/Ag Nanoclusters. Nano Lett. 2013, 13, 309–314. DOI: 10.1021/nl304283c

29.     Xiaoqing Liu, Angelica Niazov-Elkan, Fuan Wang, Itamar Willner*, Switching Photonic and Electrochemical Functions of a DNAzyme by DNA Machines. Nano Lett. 2013, 13, 219–225. DOI: 10.1021/nl303894h

30.     Fuan Wang, Xiaoqing Liu, Itamar Willner*, Integration of Photoswitchable Proteins, Photosynthetic Reaction Centers and Semiconductor/Biomolecule Hybrids with Electrode Supports for Optobioelectronic Applications. Adv. Mater. 2013, 25, 349–377. DOI: 10.1002/adma.201201772

31.     Etery Sharon, Xiaoqing Liu, Ronit Freeman, Omer Yehezkeli, Itamar Willner*, Label-Free Analysis of Thrombin or Hg2+ Ions by Nucleic Acid-Functionalized Graphene Oxide Matrices Assembled on Field-Effect Transistors. Electroanalysis 2013, 25, 851–856. DOI: 10.1002/elan.201200581

32.     Xiaoqing Liu, Ruth Aizen, Ronit Freeman, Omer Yehezkeli, Itamar Willner*, Multiplexed Aptasensors and Amplified DNA Sensors Using Functionalized Graphene Oxide: Application for Logic Gate Operations. ACS Nano 2012, 6, 3553–3563. DOI: 10.1021/nn300598q

33.     Xiaoqing Liu, Freeman Ronit, Itamar Willner*, Amplified Fluorescence Aptamer-Based Sensors Using Exonuclease III for the Regeneration of the Analyte. Chem. Eur. J. 2012, 18, 2207–2211. DOI: 10.1002/chem.201103342

34.     Zhanxia Zhang, Etery Sharon, Ronit Freeman, Xiaoqing Liu, Itamar Willner*, Fluorescence Detection of DNA, Adenosine-5'-Triphosphate and Telomerase Activity by Zn(II)-Protoporphyrin IX/G-Quadruplex as Label. Anal. Chem. 2012, 84, 4789–4797. DOI: 10.1021/ac300348v

35.     Ronit Freeman†, Xiaoqing Liu†, Itamar Willner*, Chemiluminescent and Chemiluminescence Resonance Energy Transfer (CRET) Detection of DNA, Metal Ions, and Aptamer_Substrate Complexes Using Hemin/G-Quadruplexes and CdSe/ZnS Quantum Dots. J. Am. Chem. Soc. 2011, 133, 11597–11604. (†Equal Contribution) DOI:  10.1021/ja202639m

36.     Xiaoqing Liu, Ronit Freeman, Eyal Golub, Itamar Willner*, Chemiluminescence and Chemiluminescence Resonance Energy Transfer (CRET) Aptamer Sensors Using Catalytic Hemin/G-Quadruplexes. ACS Nano 2011, 5, 7648–7655. DOI: 10.1021/nn202799d

37.     Ronit Freeman, Xiaoqing Liu, Itamar Willner*, Amplified Multiplexed Analysis of DNA by the Exonuclease III-Catalyzed Regeneration of the Target DNA in the Presence of Functionalized Semiconductor Quantum Dots. Nano Lett. 2011, 11, 4456–4461. DOI: 10.1021/nl202761g

38.     Gilad Pelossof, Ran Tel-Vered, Xiaoqing Liu, Itamar Willner*, Amplified Surface Plasmon Resonance-Based DNA Biosensors, Aptasensors, and Hg2+ Sensors Using Hemin/G-Quadruplexes and Au Nanoparticles. Chem. Eur. J. 2011, 17, 8904–8912. DOI: 10.1002/chem.201100601

39.     Xiaoqing Liu, Fuan Wang, Yuling Wang, Shuyun Zhu, Guobao Xu*, Functionalized Single-Walled Carbon Nanohorns for Electrochemical Biosensing. Biosens. Bioelectron. 2010, 25, 2194-2199. DOI: 10.1016/j.bios.2010.02.027

40.     Xiaoqing Liu, Fuan Wang, Shuang Han, Lihong Shi, Guobao Xu*, Self-Assembly of gold Nanoparticles/Electroactive Polyelectrolyte Multilayer Films for Tunable Electrocatalysis. Electroanalysis 2010, 22, 963-969. DOI: 10.1002/elan.200900479

41.     Fuan Wang, Xiaoqing Liu, Gaiping Li, Dan Li, Shaojun Dong*, Selective Electrodissolution of Inorganic Ions/DNA Multilayer Film for Tunable DNA Release. J. Mater. Chem. 2009, 19, 286–291. DOI: 10.1039/B812940A

42.     Lihong Shi, Xiaoqing Liu, Wenxin Niu, Haijuan Li, Shuang Han, Jiuan Chen, Guobao Xu*, Hydrogen Peroxide Biosensor Based on Direct Electrochemistry of Soybean Peroxidase Immobilized on Single-Walled Carbon Nanohorn Modified Electrode. Biosens. Bioelectron. 2009, 24, 1159–1163. DOI: 10.1016/j.bios.2008.07.001

43.     Wenxin Niu, Shanliang Zheng, Dawei Wang, Xiaoqing Liu, Haijuan Li, Shuang Han, Jiuan Chen, Zhiyong Tang*, Guobao Xu*, Selective Synthesis of Single-Crystalline Rhombic Dodecahedral, Octahedral, and Cubic Gold Nanocrystals. J. Am. Chem. Soc. 2009, 131, 697–703. DOI: 10.1021/ja804115r

44.     Haijuan Li, Jiuan Chen, Shuang Han, Wenxin Niu, Xiaoqing Liu, Guobao Xu*, Electrochemiluminescence from Tris(2,2'-Bipyridyl)Ruthenium(II)-Graphene-Nafion Modified Electrode. Talanta 2009, 79, 165-170. DOI: 10.1016/j.talanta.2009.03.020

45.     Haijuan Li, Lihong Shi, Xiaoqing Liu, Wenxin Niu, Guobao Xu*, Determination of Isocyanates by Capillary Electrophoresis with Tris(2,2'-bipyridine)ruthenium(II) Electrochemiluminescence. Electrophoresis 2009, 30, 3926–39316. DOI: 10.1002/elps.200900281

46.     Xiaoqing Liu, Lihong Shi, Wenxin Niu, Haijuan Li, Guobao Xu*, Amperometric Glucose Biosensor Based on Single-Walled Carbon Nanohorns. Biosens. Bioelectron. 2008, 23, 1887–1890. DOI: 10.1016/j.bios.2008.02.016

47.     Xiaoqing Liu, Wenxin Niu, Haijuan Li, Shuang Han, Lihong Shi, Guobao Xu*, Glucose Biosensor Based on Gold Nanoparticle-Catalyzed Luminol Electrochemiluminescence on a Three-Dimensional Sol-Gel Network. Electrochem. Commun. 2008, 10, 1250–1253. DOI: 10.1016/j.elecom.2008.06.009

48.     Haijuan Li, Xiaoqing Liu, Wenxin Niu, Shuyun Zhu, Lishuang Fan, Lihong Shi, Guobao Xu*, Capillary Electrochromatography with Tris(2,2'-bipyridyl) Ruthenium(II) Electrochemiluminescent Detection. Electrophoresis 2008, 29, 4475–4481. DOI: 10.1002/elps.200800088

49.     Fuan Wang, Dan Li, Gaiping Li, Xiaoqing Liu, Shaojun Dong*, Electrodissolution of Inorganic ions/DNA Multilayer Film for Tunable DNA Release. Biomacromolecules 2008, 9, 2645–2652. DOI: 10.1021/bm800766t

50.     Fuan Wang, Jianlong Wang, Xiaoqing Liu, Shaojun Dong*, Nanoparticle-amplified Surface Plasmon Resonance Study of Protein Conformational Change at Interface. Talanta 2008, 77, 628–634. DOI: 10.1016/j.talanta.2008.06.042

51.     Shuyun Zhu, Lishuang Fan, Xiaoqing Liu, Lihong Shi, Haijuan Li, Shuang Han, Guobao Xu*. Determination of Concentrated Hydrogen Peroxide at Single-Walled Carbon Nanohorn Paste Electrode. Electrochem. Commun. 2008, 10, 695–698. DOI: 10.1016/j.elecom.2008.02.020

52.     Wenxin Niu, Zhi-Yuan Li, Lihong Shi, Xiaoqing Liu, Haijuan Li, Shuang Han, Jiuan Chen, Guobao Xu*, Seed-mediated Growth of Nearly Monodisperse Palladium Nanocubes with Controllable Sizes, Cryst. Growth. Des. 2008, 8, 4440-4444. DOI: 10.1021/cg8002433

53.     Xiaoqing Liu, Lihong Shi, Wenxin Niu, Haijuan Li, Guobao Xu*, Environmentally Friendly and Highly Sensitive Ruthenium(II) Tris(2,2'-bipyridyl) Electrochemiluminescent System Using 2-(dibutylamino)ethanol as Co-Reactant. Angew. Chem. Int. Ed. 2007, 46, 421–424. DOI: 10.1002/anie.200603491

54.     Xiaoqing Liu, Lihong Shi, Haijuan Li, Wenxin Niu, Guobao Xu*, Tris(2,2'-bipyridyl)ruthenium(II) Electrochemiluminescent Detection of Coreactants Containing Aromatic Diol Group by the Interaction Between Diol and Borate Anion. Electrochem. Commun. 2007, 9, 2666–2670. DOI: 10.1016/j.elecom.2007.08.017

55.     Jing Li, Minghua Huang, Xiaoqing Liu, Hui Wei, Yuanhong Xu, Guobao Xu, Erkang Wang*, Enhanced Electrochemiluminescence Sensor from Tris(2,2'-Bipyridyl)Ruthenium(II) Incorporated into MCM-41 and an Ionic Liquid-Based Carbon Paste Electrode. Analyst 2007, 132, 687–691. DOI: 10.1039/B701842H

56.     Shuang Han, Junfeng Zhai, Lihong Shi, Xiaoqing Liu, Haijuan Li, Guobao Xu*, Rotating Minidisk-Disk Electrodes, Electrochem. Commun. 2007, 9, 1434-1438. DOI: 10.1016/j.elecom.2007.01.052

57.     Lianzhe Hu, Haijuan Li, Shuyun Zhu, Lishuang Fan, Lihong Shi, Xiaoqing Liu, Guobao Xu*, Cathodic Electrochemiluminescence in Aqueous Solutions at Bismuth Electrodes. Chem. Commun. 2007, 40, 4146-4148. DOI: 10.1039/B709612G

58.     Lihong Shi, Xiaoqing Liu, Haijuan Li, Wenxin Niu, Guobao Xu*, Application of Ceramic Carbon Materials for Solid-Phase Extraction of Organic Compounds. Anal. Chem. 2006, 78, 1345–1348. DOI: 10.1021/ac051894e

59.     Lihong Shi, Xiaoqing Liu, Haijuan Li, Guobao Xu*, Electrochemiluminescent Detection Based on Solid-Phase Extraction at Tris(2,2'-Bipyridyl)Ruthenium(II)-Modified Ceramic Carbon Electrode. Anal. Chem. 2006, 78, 7330–7334. DOI: 10.1021/ac060767v

60.     Lihong Shi, Xiaoqing Liu, Haijuan Li, Guobao Xu*, Determination of Total Calcium in Plasma by Flow Injection Analysis with Tris(2,2׳-Bipyridyl)Ruthenium(II) Electrochemiluminescent Detection. Electroanalysis 2006, 18, 1584–1589. DOI: 10.1002/elan.200603555

专利

1.      Itamar Willner, Fuan Wang, Chun-hua Lu, Xiaoqing Liu, Lina Freage, Compositions, kits, uses and methods for amplified detection of an analyte, United States Patent 9809846, Application Number:14/586214, Publication Date: 11/07/2017, Filing Date: 12/30/2014

2.  发明人: 徐国宝,刘晓庆,史立红,专利名称:环境友好的高灵敏电化学发光检测方法, 专利号:200510016848.4, 公开号: CN1696666,授权公告日:2010.01.27

3.  发明人: 徐国宝, 史立红, 刘晓庆, 牛文新, 专利名称:三联吡啶钌电化学发光测定血浆钙的方法,专利号: 200510017231.4, 公开号:CN1773259,授权公告日: 2009.05.20

4.  发明人:徐国宝, 史立红,刘晓庆,李海娟,专利名称:溶胶-凝胶法制备的碳陶瓷材料的应用,专利号: 200510017012.6,公开号:CN1736581,授权公告日:2007.10.10

5.  发明人:徐国宝,史立红,刘晓庆,专利名称: Nafion-碳陶瓷复合材料电化学发光传感器的制备方法,专利号:CN200510016770.6, 公开号: CN1693285,授权公告日:2007.05.09

6.  发明人:李景虹;王美佳;刘晓庆, 专利名称:脱氧核糖核酸电化学纳米传感器的制备方法, 专利号: 03127158.8, 公开号:CN1525163,授权公告日:2005.08.17