杜宇昊

博士 , 副教授
研究方向: 化学生物学 有机化学 表观遗传学
联系电话:
Email: dyh@whu.edu.cn

2012.4-至今武汉大学化学与分子科学学院副教授

2010.9-2011.12, Wake Forest University, 博士后合作导师: Lindsay R. Comstock

2009-2010 Univerity of Virginia,访问学者,导师:Lin Pu

2007-2008 法国University of Grenoble 3,联合培养,导师:Jean-Francois Constant

2004.92010.7,  武汉大学有机化学博士导师周翔教授

2000.92004.7,  武汉大学化学学士导师周翔教授


   一直从事化学生物学的研究,在小分子探针、修饰核酸、蛋白抑制剂领域有着扎实的工作基础和经验积累。所在实验室为教育部长江学者特聘教授、科技部 973 首席科学家、国家杰出青年基金获得者周翔教授主持的核酸化学生物学实验室。在博士期间就从事与核酸分子探针的研究,接着在青年基金《新型可诱导DNA甲基转移酶和组蛋白甲基转移酶抑制剂的设计合成,构效关系和活性研究》及面上项目《DNA中甲基、羟甲基、醛基胞嘧啶多位点检测及胞嘧啶羟甲基修饰的方法研究》的资助下,开展了独立研究工作。


发表论文:

(1) Liu, Yinong ; Zhong, Cheng ; He, Zhiyong ; Rao, Shuang; Su, Haomiao; Wu, Fan; Fu, Boshi; Wu, Jinjun; Song, Yanyan; ; Zhou, Xiang; Du, Yuhao; Reversible photoregulation of DNA B-Z transition by a photochromic nucleoside. Sensors and Actuators B: Chemical 20182151-2154.

(2) Rao, Shuang ; Chen, Yuqi; Hong, Tingting; He, Zhiyong; Guo, Shan; Lai Han; Guo, Ge; ; Zhou, Xiang; Du, Yuhao; Simultaneous and Sensitive Detection of Multisite 5-Methylcytosine Including Non-CpG Sites at Single-5mC-Resolution. Anal. Chem. 2017, 88(21), 10547~10551.

(3) He, Zhiyong ; Chen, Yuqi; Wang, Yafen; Wang, Jiaqi; Mo, Jing; Fu, Boshi; Wang, Zijing; ; Zhou, Xiang; Du, Yuhao; A rapidly photo-activatable light-up fluorescent nucleoside and its application in DNA base variation sensing. Chem Commun (Camb) 2016, 52(55), 8545~8548.

(4) Hendrick, Charles E; Frye, Krysta S; Comstock, Lindsay R; Du, Yuhao, Fluorescent DNA labeling by N-mustard analogues of S-adenosyl-L-methionine. ChemBioChem 2012, 13(15), 2225~2233.

(5) Zhou, Xiang; Du, Yuhao; Targeting non-B-form DNA in living cells. Chem. Rec. 2013, 13(4), 371~384.

(6) Turlington, Mark; Ostrum, Samuel G; Santosh, Vishaka; Du, Yuhao; Wren, Kathryne; Lin, Tony; Sabat, Michal; Pu, Lin; From highly enantioselective catalytic reaction of 1,3-diynes with aldehydes to facile asymmetric synthesis of polycyclic compounds. J. Am. Chem. Soc. 2011, 133(30), 11780~11794.

(7) Weng, Xiaocheng; Huang, Jing; Zhang, Dan; Ma, Heng; Chen, Du, Yuhao, Dong; Zhou, Xiang ; Constant, Jean-Francois; Oligonucleotide-selenide conjugate: synthesis and its inducible sequence-specific alkylation of DNA. Bioorg. Med. Chem. 2010, 18(11), 4149-4153.

(8) Zhang, Dan; Chen, Wei; Zhang, Ming; Zhou, Yangyang; Zhou, Du, Yuhao , Xiang; Cationic N-confused porphyrin derivative as a better molecule scaffold for G-quadruplex recognition. Bioorg. Med. Chem. 2010, 8(3), 1111~11168.

(9) Turlington, Mark; Zhou, Xiang; Pu, Lin; Du, Yuhao; Highly enantioselective addition of linear alkyl alkynes to linear aldehydes. Tetrahedron Letters 2010, 51(38), 5024~5027.

(10) Huang, Jing; Weng, Xiaocheng; Zhou, XiangDu, Yuhao; Specific Recognition of DNA by Small Molecules. Current Medicinal Chemistry 2010, 17(2), 173~189